The right address depends on whether Guayaquil is the purpose of the stay or a place you must pass through. For a city visit, compare the hotel with your chosen museum and meal. For an early flight, prioritize a confirmed transfer and an arrival plan that works at the actual hour.
An appealing river view does not tell you how the last part of the journey works. Ask where the vehicle can collect you, whether reception is available for your arrival and what food options the property can arrange. Use recent, specific information about the address rather than a broad neighborhood label.
For a visit built around work, the business-travel guide compares a meeting address on Avenida Francisco de Orellana with riverfront time and covers room setup, airport pickup and billing questions.